| 31 December 2010 | Most people fist pumping | 5726 people | MTV |
| 20 December 2010 | Most valuable virtual object | 6000000 US dollar(s) | SEE Virtual Worlds |
| 19 December 2010 | Worst road losing streak, NFL team | | Detroit Lions |
| 12 December 2010 | Oldest person to complete a marathon (female) | 92/19 year(s):day(s) | Gladys Burrill |
| 12 December 2010 | Youngest female to enter the UK Top 40 singles chart | | Willow Smith |
| 11 December 2010 | Largest display of nativity sets | 2150 total number | Oasis Church |
| 11 December 2010 | Largest attendance at an ice hockey match | 104173 people | University of Michigan |
| 10 December 2010 | Largest ring binder | | Impact Enterprises, Inc. |
| 10 December 2010 | Most powerful electromagnetic rail gun | 33000000 joule(s) | Electromagnetic railgun |
| 09 December 2010 | Most people crammed into an 'old'VW Beetle | 20 people | Asbury University |
| 09 December 2010 | Most pizzas made in one hour | | Brian Edler |
| 07 December 2010 | Most people exercising to a computer programme | 2288 people | Atlanta Falcons Football Club |
| 05 December 2010 | Most matches started in consecutive regular seasons in an NFL career by a quarterback | 297 total number | Brett Favre |
| 04 December 2010 | Youngest US top 3 album act | | Jackie Evancho |
| 03 December 2010 | Most expensive map | 1800000 US dollar(s) | A New and Correct Map of the United States of North America Layd Down from the Latest ... |
| December 2010 | First arsenic-based bacteria | first | Bacteria in Mono Lake |
| 29 November 2010 | Farthest distance blowing a Malteser with a straw | 14.07 metre(s) | Ashrita Furman |
| 29 November 2010 | Farthest golf ball blow | 6.35 metre(s) | Ashirvad Zaiantchick |
| 26 November 2010 | Largest wallet | | Big Skinny Corporation |
| 26 November 2010 | Largest free-flying head-down parachuting formation (female) | 41 people | International Team |
| 23 November 2010 | Most valuable handbag | 3800000 US dollar(s) | Mouawad |
| 21 November 2010 | First gamer to reach 1,000,000,000 fans on Rock Band 3 (Harmonix, 2010) | first | Josh Ray |
| 17 November 2010 | Largest voodoo doll | 6.6 metre(s) | Fusion-io , Catherina Williams |
| 13 November 2010 | Fastest-selling digital album in the USA by a female artist | 278000 download(s) | Taylor Swift |
| 13 November 2010 | Largest collection of candle holders / chambersticks | | Tim and Cindy Duffy |
| 13 November 2010 | Fastest-selling album in the US by a female country artist | 1047000 unit(s) sold | Taylor Swift |
| 13 November 2010 | Highest pancake toss | 9.47 metre(s) | Dominic Cuzzacrea |
| 13 November 2010 | Most boxing world titles in different weight divisions | 8 total number | Manny Pacquiao |
| 10 November 2010 | Tightrope walking (unsupported) – greatest distance | | Bello Nock |
| 09 November 2010 | Fastest game of Hopscotch | 1/1.97 minute(s):second(s) | Ashrita Furman |
| 09 November 2010 | Greatest distance driven by an online controlled vehicle in 24 hours | 146.45 kilometre(s) | Mitsubishi Motors North America, Inc. |
| 06 November 2010 | Longest match, Professional Wrestling | | Shockwave Impact Wrestling |
| 06 November 2010 | Most IDPA competitions entered in one year | | Robert Briggs |
| 04 November 2010 | Most balloons burst simultaneously by arrows | 7 total number | Randy Oitker |
| 31 October 2010 | Largest Time Warp dance | | 20th Century Fox |
| 31 October 2010 | Largest Halloween gathering | 17777 people | NBC Sports , New Orleans Saints |
| 30 October 2010 | Largest jack o'lantern (size) | 821.23 dimension(s) | Scott Cully |
| 30 October 2010 | First artist to have singles enter the top 10 of the US hot 100 in successive weeks | first | Taylor Swift |
| 29 October 2010 | Largest collection of chocolate bars | | Bob Brown |
| 26 October 2010 | Largest Parade of Scion Cars | | Scion Los Angeles Region |
| 24 October 2010 | Most interceptions recorded in a game, individual | | 18 players |
| 20 October 2010 | Most expensive Barbie doll sold at auction | 302,500 US dollar(s) | Mattel |
| 20 October 2010 | Most inverts on a sit-down hydrofoil in one hour | 826 total number | Geno Yauchler |
| 17 October 2010 | Longest marathon harp playing | | Carly Syta |
| 10 October 2010 | Song sung in the most languages (Billboard Charts) | | Liquid Blue |
| 10 October 2010 | Largest can drum ensemble | | Central Michigan University |
| 10 October 2010 | Most American football field goals in 12 hours | 717 total number | Craig Pinto |
| 09 October 2010 | Farthest distance to blow a coin | 4.947 metre(s) | Ashrita Furman |
| 09 October 2010 | Fastest time to cross the continental United States by wheelchair | 12/5289.92/126/4/2 day(s):hour(s):minute(s) | Matthew Eddy |
| 09 October 2010 | Largest flyball tournament | | North American Flyball Association |
| 04 October 2010 | Largest afro (female) | 16/21/1.39 centimetre(s) | Aevin Jude Dugas |
| 03 October 2010 | Youngest Musician to Headline a Solo Concert Tour | | Ethan Bortnick |
| 02 October 2010 | Most people dressed as superheroes | 1580 people | Dreamworks' 'Megamind' |
| 01 October 2010 | Most landmarks illuminated in 24 hours | 38 total number | The Estée Lauder Companies |
| October 2010 | Most prolific record breaker on Boom Blox (EA, 2008) | | Marc Cohen |
| 30 September 2010 | Fastest wedding chapel | 99 mile(s) per hour | Best Man |
| 30 September 2010 | High score on Guitar Hero III (Female) | | Annie Leung |
| 29 September 2010 | Longest tongue (female) | 9.75 centimetre(s) | Chanel Tapper |
| 25 September 2010 | Most consecutive haircuts by a team in 24 hours | 618 total number | Pump Salon |
| 25 September 2010 | Most weeks on the US hot country songs chart | | Lee Brice |
| 25 September 2010 | Fastest motorcycle speed achieved | 605.697 kilometre(s) per hour | Rocky Robinson |
| 25 September 2010 | Largest pie, pumpkin | 1678 kilogram(s) | New Bremen Giant Pumpkin Growers |
| 25 September 2010 | Youngest person to have gallstones | 2/10 day(s) | Johnathan Reardon |
| 25 September 2010 | Largest marble game tournament | 876 people | Duncan Toys , Boy Scouts of America |
| 24 September 2010 | Fastest baseball pitch (male) | 105.1 mile(s) per hour | Aroldis Chapman |
| 23 September 2010 | Most seasons with 200 hits in a Major League Baseball career | | Ichiro Suzuki, Pete Rose |
| 23 September 2010 | First television show based on a Twitter feed | | $h*! My Dad Says |
| 23 September 2010 | Pitcher hitting the most consecutive batters | | 9 pitchers |
| 23 September 2010 | Largest macaroni and cheese | 1119.91 kilogram(s) | Cabot Creamery Cooperative , Chef John Folse & Company |
| 22 September 2010 | Largest king cake / rosca de reyes | 1847.68 kilogram(s) | Haydel's Bakery |
| 16 September 2010 | Limbo - Lowest (female) | 21.59 centimetre(s) | Shemika Campbell |
| 15 September 2010 | Fastest speed in a human-powered vehicle (female) | 121.81 kilometre(s) per hour | Barbara Buatois |
| 14 September 2010 | Youngest man to win a tennis career Grand Slam | | Rafael Nadal |
| 12 September 2010 | Largest triathlon race | 4546 people | The Nation's Triathlon |
| 12 September 2010 | First tight end to catch 1,000 passes, NFL career | first | Tony Gonzalez |
| 11 September 2010 | Largest high heel race | 967 people | Fort Wayne Women's Bureau |
| 09 September 2010 | Farthest distance to fire a pumpkin | | Ralph J. Eschborn II, Alex C. Eschborn, Eric J. Eschborn, Pete Hill, Stefan Hill, John Piel, Verne W |
| 07 September 2010 | Most points scored in a playoff game, WNBA | | Angel McCoughtry |
| 03 September 2010 | Largest hokey cokey dance | 7384 people | FRY Fest |
| 03 September 2010 | Fastest streamlined motorcycle speed (female) | 229.92 kilometre(s) per hour | Erin Hunter |
| 03 September 2010 | Longest contract in NHL ice hockey | | Ilya Kovalchuk, Rick DiPietro |
| 01 September 2010 | Oldest person to obtain a pilot's licence | | James Collins Warren |
| 31 August 2010 | Longest living quadriplegic | | Walton Dutcher, Jr. |
| 30 August 2010 | Highest insured hair | 1000000 US dollar(s) | Troy Polamalu |
| 28 August 2010 | Longest domestic cat (ever) | 123 centimetre(s) | Mymains Stewart Gilligan |
| 28 August 2010 | Largest pool tournament | 5361 people | American Poolplayers Association |
| 27 August 2010 | Roman rings hanging duration (iron cross) | | Zak Kerkoulas |
| 27 August 2010 | Longest seesaw / teeter totter | 24.13/2.82 metre(s) | Ashrita Furman |
| 25 August 2010 | Longest journey by dragon boat | 294.58 kilometre(s) | Team Beauties & Barnacles |
| 22 August 2010 | Longest stoppie (nose wheelie) on a motocross bike | 86.2 kilometre(s) | Gary Harding |
| 21 August 2010 | Longest chain of shoes | | South Main Baptist Church |
| 19 August 2010 | Fastest mile on a space hopper | 13 minute(s):second(s) | Ashrita Furman |
| 14 August 2010 | Largest boat tie-up | | Lake Cumberland Association |
| 14 August 2010 | Heaviest sumo deadlift in one hour (female) | 47552.9 kilogram(s) | Thienna Ho |
| 14 August 2010 | Most R&B no.1s in the US | | Usher |
| 09 August 2010 | Largest game of gaga ball | 481 people | Briarwood Day Camp |
| 07 August 2010 | Fastest lunge mile - men | 25/21.11 minute(s):second(s) | Jamasen Rodriguez |
| 07 August 2010 | Most Caesar salads made in one hour | | Bob Blumer |
| 06 August 2010 | Largest collection of personal scrapbooks | 2396 total number | Hugh Hefner |
| 04 August 2010 | Youngest person to hit 600 home runs in a Major League Baseball career | | Alex Rodriguez |
| 04 August 2010 | Fastest 50 m by string/can stilt walking | 9.7 second(s) | Steven Bell |
| 04 August 2010 | Youngest player to hit 600 career home runs | | Alex Rodriguez |
| August 2010 | Fastest aircraft, civil | | Gulfstream G650 |
| 01 August 2010 | Most skateboard axle stalls in one minute | 31 total number | Annika Vrklan |
| 30 July 2010 | Most skateboard frontside boneless in 30 seconds | | Alex Sorgente |
| 29 July 2010 | Largest simultaneous yo-yo | 2036 people | Yomega Corporation , Boys' Life Magazine |
| 29 July 2010 | Most prolific professional blogger | | Darren Murph |
| 25 July 2010 | Highest rated animated TV sci-fi | | Futurama |
| 25 July 2010 | Most successful horror film series | 733271976 US dollar(s) | SAW |
| 24 July 2010 | Longest tail on a pony | | Janine Sparks |
| 23 July 2010 | Highest flight by solar-powered spyplane (UAV) | | Zephyr |
| 18 July 2010 | Fastest time to peel 50 lbs of onions | 2/39 minute(s):second(s) | Bob Blumer |
| 17 July 2010 | Most no.1s on the US contemporary Jazz Album chart | 14 total number | Kenny G |
| 11 July 2010 | Farthest distance travelled controlling a golf ball | 2903 metre(s) | Ashrita Furman |
| 10 July 2010 | Most successive US No.1 albums by a solo artist | 6 total number | Eminem |
| 03 July 2010 | Fastest differential speed – propeller-powered land yacht | 2.8 total number | Rick Cavallaro, John Borton |
| July 2010 | Thinnest 5x zoom digital camera | 15.2 millimetre(s) | Kodak's EasyShare M590 14 MP |
| July 2010 | Most successful sports movie franchise | 1251372491 US dollar(s) | Rocky franchise |
| July 2010 | Most Viewed Sci Fi Animation Show | 4000000 people | Star Wars: The Clone Wars |
| 29 June 2010 | Most triples in a game | | 28 players |
| 26 June 2010 | Pitcher with most consecutive scoreless games | | Arthur Rhodes |
| 26 June 2010 | Farthest distance wakeboarding in 24 hours (team) | 819.49 kilometre(s) | Wake Nation Cincinnati |
| 23 June 2010 | Greenest ammunition and most thoroughly tested - enhanced performance rounds | | Enhanced Performance Rounds |
| 19 June 2010 | Longest marathon tenpin bowling | 134/57 hour(s):minute(s) | Stephen Shanabrook |
| 18 June 2010 | Tallest bloom | 3.1 metre(s) | Louis Ricciardiello |
| 16 June 2010 | Most numbers identified by a horse in one minute | | Lukas |
| 13 June 2010 | Largest trail riding competition | 974 people | American Competitive Trail Horse Assocation |
| 12 June 2010 | Most eggs balanced by an individual | 888 total number | Ashrita Furman |
| 09 June 2010 | Highest score on PAC-Man Championship Edition (Namco Bandai, 2010) | 451660 point(s) | Christopher Zupan |
| 08 June 2010 | Longest ears on a dog - living | 31.1 centimetre(s) | Harbor |
| 05 June 2010 | Most basketball free throws in 30 seconds (male) | 33 total number | Bob J. Fisher |
| 02 June 2010 | Longest marathon playing poker by an individual | 115 hour(s):minute(s):second(s) | Phil Laak |
| 31 May 2010 | Fastest lap on Crash Nitro Kart (Universal, 2003) | | Alex Herrera |
| 28 May 2010 | Oldest chorus line member | | Genda Guilfoyle |
| 28 May 2010 | Fastest completion of Sonic the Hedgehog 3 (Megadrive/Genesis) | 42/10.6 minute(s):second(s) | Steven Meyer |
| 26 May 2010 | Longest flight at hypersonic speed | | X-51A Waverider |
| 26 May 2010 | Most people to disappear in an illusion | 100 people | Criss Angel |
| 24 May 2010 | Longest wheelie on Grand Theft Auto IV | | Brendan Herlacher |
| 22 May 2010 | Highest Score on Recipe Lab on Chocolate Shop Frenzy (Digital Chocolate, 2008) | | Jennifer Jacobs |
| 20 May 2010 | Longest time continuously controlling a football (male) | 21:01:00 hour(s):minute(s):second(s) | Abraham Muñoz |
| 19 May 2010 | Longest continuous burn of oil spill | | Elastec / American Marine |
| 18 May 2010 | Oldest obituary photo | | Mary L. Reiss |
| 17 May 2010 | Highest score on Home Run Pinball in The Bigs 2 (2K Sports, 2009) | | Christopher Zupan |
| 17 May 2010 | Fastest completion of 'Vidmaster: Classic'on Halo: ODST (Microsoft, 2009) | 2/33 minute(s):second(s) | Geno Belfatto |
| 15 May 2010 | Most family members to graduate from the same university | | Wayne family of Marion, Louisiana |
| 08 May 2010 | Largest clog dance | 2605 people | Pella Historical Society |
| 07 May 2010 | Most runs batted in by a player in his first game | | Starlin Castro |
| 07 May 2010 | Oldest pitcher to record a shutout | | Jamie Moyer |
| 03 May 2010 | Fastest time to peel and eat a lemon | 8.25 second(s) | Ashrita Furman |
| May 2010 | Highest paid child actor on TV by episode | 250000 US dollar(s) | Angus T. Jones |
| May 2010 | Oldest chart duo | | Carole King, James Taylor |
| 26 April 2010 | Longest serving Den Mother | | Adele Trapp |
| 24 April 2010 | Most US no.1 music videos | 9 total number | Madonna |
| 22 April 2010 | Longest time standing on a globe | 43/56 minute(s):second(s) | Ashrita Furman |
| 20 April 2010 | Longest journey in an excavator / digger | 5127.22 kilometre(s) | Neil Smith |
| 20 April 2010 | Highest commercial decelerator descent | | Sky Jump Las Vegas |
| 20 April 2010 | Largest accidental marine oil spill | 779000000/4900000 litre(s) | Deepwater Horizon |
| 14 April 2010 | Youngest NBA scoring champion | 21/197 year(s):day(s) | Kevin Durant |
| 12 April 2010 | Most football touches in 30 seconds (male) | 252 total number | Parker Kuklinski |
| 11 April 2010 | Longest duration flight by helium balloons | 13/36/57 hour(s):minute(s):second(s) | Jonathan Trappe |
| 07 April 2010 | Most NBA games won by a coach | | Don Nelson |
| 06 April 2010 | Largest gathering of people wearing fleece blankets | 42690 people | Angels Baseball |
| 05 April 2010 | Highest score on Asteroids (Atari, 1979) | | John McAllister |
| 05 April 2010 | Most women in orbit | 3 people | Naoko Yamazaki, Dorothy Metcalf-Lindenburger, Stephanie Wilson |
| 01 April 2010 | Largest population of centenarians | 53364 people | USA |
| 27 March 2010 | Fastest 100 metres frog jumping | 7/18 minute(s):second(s) | Ashrita Furman |
| 26 March 2010 | Longest ramp jump - snowmobile | | Paul Thacker |
| 26 March 2010 | Longest distance water sliding in 24 hours in multiple venues (team) | | Great Wolf Resorts |
| 25 March 2010 | Longest prison sentence for computer hacking | | Albert Gonzalez |
| 23 March 2010 | First commercial passenger space aircraft | first | Virgin Galactic SpaceShipTwo, aka Virgin Spaceship Enterprise |
| 22 March 2010 | Largest baseball contract - catcher | 184000000 US dollar(s) | Joe Mauer |
| 21 March 2010 | Youngest drummer | | Julian Pavone |
| 19 March 2010 | Youngest individual to score 15,000 points in an NBA career | | LeBron James |
| 19 March 2010 | Youngest individual to score 15,000 points, NBA career | | LeBron James |
| 14 March 2010 | Largest cereal treat | 4678.35 kilogram(s) | Natalie Knight |
| 10 March 2010 | Most countries played in by a basketball team | | Harlem Globetrotters |
| 08 March 2010 | Most meatballs eaten in one minute | 29 total number | Takeru Kobayashi |
| 07 March 2010 | Most Oscar nominations - Best Foreign Language Film | 38 total number | France |
| 07 March 2010 | Most consecutive years of Oscars coverage by an entertainment reporter | | Bob Thomas |
| 07 March 2010 | First female to win an Oscar for best director | first | Kathryn Bigelow |
| 02 March 2010 | Largest collection of hats | 100336 total number | Roger Buckey Legried |
| 02 March 2010 | First perfect game in MLB 2K10 (2K Sports, 2010) | first | Wade McGilberry |
| 27 February 2010 | First monster truck backflip in a scored competition | 2010/2/27 first | Cam McQueen |
| 26 February 2010 | Largest ice maze | | Roaming Buffaloes |
| 23 February 2010 | Youngest basketball player to appear in 1,000 games in NBA career | | Kobe Bryant |
| 22 February 2010 | Largest collection of yo-yos | 4586 total number | Lucky Meisenheimer |
| 20 February 2010 | Most successful reggae artist in the US | | Bob Marley & The Wailers |
| 14 February 2010 | Largest attendance at a basketball game | 108713 people | NBA All-Star Game 2010 |
| 13 February 2010 | Most points scored as Kobe Bryant on NBA 2K10 | | Chico Cora |
| 13 February 2010 | Largest trading card | | Panini America |
| 12 February 2010 | Most points in the first half of NBA 2K10 | | Cody Redrick, Brandon McJunlain |
| 11 February 2010 | Most assists playing NBA 2K10 | | Andrew Frost, J.R. Wildy |
| 11 February 2010 | First successful kill of a ballistic missile by an airborne laser system | | A US airborne laser prototype weapon system |
| 10 February 2010 | Most steals playing NBA 2K10 | | Wesley Parker |
| 08 February 2010 | Largest collection of clocks | 1509 total number | Jack Schoff |
| 07 February 2010 | Largest database of videogame features | | Electronic Entertainment Design and Research |
| 07 February 2010 | Oldest player to score in the NFL Super Bowl | | Matt Stover |
| 07 February 2010 | Oldest Super Bowl player | | Matt Stover |
| 06 February 2010 | Fastest-selling US digital download by a female | 325000 unit(s) sold | Taylor Swift |
| 06 February 2010 | Tallest bread sculpture | 5.58 metre(s) | Ciril Hitz, Robert Zielinski & Mitch Stamm |
| 06 February 2010 | Longest gap between US &UK album hits | | The Chipmunks |
| 02 February 2010 | Youngest player to block 1,000 shots | | Josh Smith |
| 01 February 2010 | Most people skipping (multiple venue) | 70880 people | California Association for Health, Physical Education, Recreation & Dance (CAHPERD) |
| February 2010 | Most chemicals in an air quality calibration gas cylinder | | Linde Electronics and Specialty Gases |
| 31 January 2010 | Highest hippy jump on a snowskate | 47 centimetre(s) | Kyle Williams |
| 31 January 2010 | Highest Air on Skis on a Superpipe | 7.58 metre(s) | Peter Olenick |
| 31 January 2010 | Most three-point field goals in an NBA quarter by a team | | Cleveland Cavaliers |
| 30 January 2010 | Highest snowboard air on a superpipe | | Shaun White |
| 30 January 2010 | Most consecutive gold medals in Winter X Games Snowboarder X | | Nate Holland |
| 29 January 2010 | Greatest distance to spit a table tennis ball | 12.83 metre(s) | Ashrita Furman |
| 29 January 2010 | Highest ollie (kickflip) on a snowskate board | 72.4 centimetre(s) | Phil Smage |
| 29 January 2010 | Most snowskate kickflips in 30 seconds | | Max Hilty |
| 28 January 2010 | Highest score on Nemesis (Konami, 1985) | | Joe Martin |
| 28 January 2010 | Greatest distance juggling on a pogo stick | 6.44 kilometre(s) | Ashrita Furman |
| 26 January 2010 | Most hair clips on the head | | Jennifer Jacobs |
| 21 January 2010 | Most money raised for charity through head shaving - individual | 121000 US dollar(s) | Dr. William Dorfman |
| 19 January 2010 | Largest winekeeper | | William Eccleston |
| 19 January 2010 | Tallest horse living | | Big Jake |
| 18 January 2010 | Largest collection of film cameras | 894 total number | Richard LaRiviere |
| 09 January 2010 | Tallest cookie tower | 1.83 metre(s) | Girl Scouts of Nassau County |
| 07 January 2010 | Fastest completion of Doctor Robotnik''s Mean Bean Machine (SEGA, 1994) | | David Greiner |
| 03 January 2010 | Most combined yards from scrimmage in an NFL season | 2509 yard(s) | Chris Johnson |
| January 2010 | First evidence of evolution without DNA | first | Unknown |
| 2010 | Largest collection of two-headed animals | | Todd Ray |
| 2010 | Longest running TV soap opera | | Coronation Street |
| 2010 | Most expensive painting by a living artist | 110000000 US dollar(s) | Jasper Johns |
| 2010 | Most flying discs (Frisbees) caught and held in the mouth by a dog | 7 total number | Edward Watson’s dog Rose |
| 2010 | Most weeks on US Hot Digital Songs chart | | Lady Gaga aka Stefani Joanne Angelina Germanotta |
| 2010 | Largest migrant on land | | American bison (Bison bison) |
| 2010 | Most NBA coaching victories, career | | Don Nelson |
| 2010 | Most consecutive seasons with 200 hits in a Major League Baseball career | 200 total number | Ichiro Suzuki |
| 2010 | Highest-rated TV spy show | | Archer |
| 2010 | Latest technology for search dogs | first | Canine Detection Research Institute |
| 2010 | Female artist with the most US no.1 singles in a year | first | Rihanna |
| 2010 | Largest cruiser fleet | 22 total number | US Navy |
| 2010 | Highest-rated new show (US) | 19340000 people | Hawaii Five-0 |
| 2010 | 21st century’s top-selling album act (USA) | 32241000 unit(s) sold | Eminem |
| 2010 | Most ejections in a Major League Baseball (MLB) career | total number | Bobby Cox |
| 2010 | Most portrayed US Detective | | Ellery Queen |
| 2010 | Least valuable art collection in a public museum | | Museum of Bad Art |
| 2010 | Stickiest salamander | | Northern slimy salamander (Plethodon glutinosus) |
| 2010 | First demonstration of 3D film | first | Unknown |
| 2010 | Most environmentally friendly bomb detectors | first | University of Colorado |
| 2010 | Heaviest woman to give birth | | Donna Simpson |
| 2010 | Only artist in US chart history to have seven singles debut in the top 10 of the hot 100 | first | Taylor Swift |
| 2010 | Most daytime Emmys won | | Sesame Street |
| 2010 | Worst playoff team in NFL history | first | Seattle Seahawks |
| 2010 | Most consecutive playoff appearances, NFL team | | Dallas Cowboys, Indianapolis Colts |
| 2010 | Largest soaps &cosmetics co | 78938000000 US dollar(s) | Procter & Gamble |
| 2010 | Longest rail network | | United States Rail Network |
| 2010 | Best selling TV DVD single | | The Pacific |
| 2010 | Most Snowboard SuperPipe medals X Games - women (winter) | | Kelly Clark |
| 2010 | English National Championships (Tiddlywinks) | 8 total number | Larry Kahn |
| 2010 | Most consecutive hits in an inning | | Colorado Rockies |
| 2010 | Most consecutive games without an error, first base | | Casey Kotchman |
| 2010 | Rapper with the most no.1 albums in the UK | | Eminem |
| 2010 | Rapper with the most us R&B hits | | Ludacris (aka Christopher Bridges) |
| 2006-2010 | Most consecutive wins of Male Vocalist of the Year at the Academy of Country Music Awards | | Brad Paisley |
| 2010 | Most expensive living artist at private sale | 110000000 US dollar(s) | Flag (1958), by Jasper Johns |
| 2010 | Most consecutive Top 10 hits on the Hot Country Songs chart | first | George Strait |
| 2010 | Fewest games to reach 600 receptions in an NFL career | | Anquan Boldin |
| 2010 | Most country no.1s for a female artist in the US | | Reba McEntire, Carrie Underwood |
| 2010 | Largest sportswear company | 19014000000 US dollar(s) | Nike |
| 2010 | Most points in an NFL career, American Football | | Morten Andersen |
| 2010 | Most gold medals won at the Summer and Winter Olympics (country) | 1020 total number | USA |
| 2010 | Largest aircraft carrier fleet | | US Navy |
| 2010 | Most official development assistance | 30200000000 US dollar(s) | United States |
| 2010 | Highest box office film gross - opening weekend (2010) | 62785337 US dollar(s) | Inception |
| 2010 | Most pinch-hit home runs in a Major League Baseball career | | Matt Stairs |