According to Official Guinness Records,
The National Football League (NFL) record for most interceptions recorded in a game by an individual is 4 held by 18 players, most recently accomplished by DeAngelo Hall (USA) while playing for the Washington Redskins against the Chicago Bears (both USA) on 24 October 2010.
For a complete list of 2010 records, please visit 2010 Guinness Records in United States.