| 31 December 2006 | Oldest people connecting on an NFL touchdown pass | | Vinny Testaverde, Troy Brown |
| 29 December 2006 | Largest menorah | 32/28 metre(s) | Shmuel Butman |
| 24 December 2006 | Furthest javelin throw in Carl Lewis Athletics 2000 | | Tom Duncan |
| 23 December 2006 | Largest ensemble of slide flutes | | Kathleen Fainelli |
| 13 December 2006 | Most people reading aloud simultaneously, multiple locations | 223363 people | Walden Media |
| 05 December 2006 | Highest tenpin bowling backwards single game score | 278 point(s) | James Cripps |
| 25 November 2006 | Fastest 100 metre sprint in Carl Lewis Athletics 2000 | | Tom Duncan |
| 20 November 2006 | Highest word total on Wordtris (Realtime Associates, 1991) | 184 point(s) | Brenda Peavler |
| 18 November 2006 | Spinning top - duration | 7/1/14 hour(s):minute(s):second(s) | Ashrita Furman |
| 18 November 2006 | Largest off licence (liquor store) | 9297.13 square metre(s) | Henry Sawaged |
| 16 November 2006 | Fastest speed barefoot waterskiing (female) | 154.63 kilometre(s) per hour | Teresa L. Wallace |
| 11 November 2006 | Most road wins consecutively in an NHL ice hockey season start | | Buffalo Sabres |
| 07 November 2006 | Smallest police dog | | Midge |
| 05 November 2006 | Fastest time to complete the New York Wheelchair Marathon (male) | 1/29/22 hour(s):minute(s):second(s) | Kurt Fearnley |
| 26 October 2006 | Most wins consecutively in an NHL ice hockey season start | | Buffalo Sabres, Toronto Maple Leafs |
| 10 October 2006 | Most expensive atlas | 2136000 US dollar(s) | Ptolemy's Cosmographia, 1477 |
| 08 October 2006 | First person to score two interception returns over 100 yards in NFL history | first | Lito Sheppard |
| October 2006 | Smallest robotic hand | 1 millimetre(s) | Hand developed by the University of California |
| October 2006 | Largest collection of earrings | 37706 total number | Carol McFadden |
| 30 September 2006 | Fastest time to complete three marathons in three days (male) | 8/11/8 hour(s):minute(s):second(s) | Johan Oosthuizen |
| 29 September 2006 | Largest popcorn ball | 3423 kilogram(s) | Unknown |
| 18 September 2006 | Most powerful jet engine on a fighter aircraft | 128100 newton(s) | F-35 Lighting II JSF |
| 17 September 2006 | Most jalapeno chilli peppers eaten in one minute | 16 total number | Alfredo Hernandes |
| 14 September 2006 | First bionic arm fitted on an individual (female) | first | Claudia Mitchell |
| 14 September 2006 | Most telephone directories torn in three minutes (male) | 56 total number | Edward Charon |
| 10 September 2006 | Highest winning margin in NHL 2004 (PlayStation 2) | 12 point(s) | Terence O'Neil |
| 09 September 2006 | Most parachute jumps in 24 hours | | Jay Stokes |
| 07 September 2006 | Oldest ballet dancer (male) | | Frank Galey |
| 05 September 2006 | Largest Exhibit of Two-Headed Animals | | Leonard Sonnenschein |
| 02 September 2006 | Oldest Kuchipudi dancer | 59 year(s):day(s) | Anuradha Subramanian |
| 01 September 2006 | Largest horseshoe sculpture | 1071 total number | Donnie Faulk |
| 30 August 2006 | Heaviest kohlrabi | | Scott Robb |
| 30 August 2006 | Most clubs juggled | 8 total number | Anthony Gatto |
| 27 August 2006 | Most rebounds in a WNBA postseason match | 23 total number | Cheryl Ford |
| 27 August 2006 | Largest popcorn sculpture | 20/10/12/9/11688 metre(s) | Sri Chinmoy Centre |
| 24 August 2006 | Largest joist hanger | | Frankie Emerson |
| 23 August 2006 | Fastest diesel-engined car (prototype) | 563.418 kilometre(s) per hour | Andy Green |
| 20 August 2006 | First row across the Atlantic west to east from USA land to land by a team of four | first | Brad Vickers, Dylan Le Valley, Greg Spooner, Jordan Hanssen |
| 18 August 2006 | Longest baseball match of nine innings | | Fenway Park |
| 15 August 2006 | Largest collection of mushroom-related items | 263 total number | Shara Hoffman |
| 05 August 2006 | Most consecutive footbag kicks in ten minutes - doubles | 1415 total number | Paul Vorvick and Tricia George |
| 04 August 2006 | First Double Backflip on a Motorcycle | first | Travis Pastrana |
| 25 July 2006 | Most swearing in a videogame | 5688/31000 total number | Scarface: The World is Yours (Sierra, 2006) |
| 18 July 2006 | Greatest distance on a human powered vehicle in 24 hours | | Greg Kolodziejzyk |
| 14 July 2006 | Fastest time to bend ten nails | 21.13 minute(s):second(s) | Chad Netherland |
| 08 July 2006 | Longest canoe | 45.44 metre(s) | Howard Whitten |
| 08 July 2006 | Most BASE jumps in 24 hours | 201 total number | Dan Schilling |
| 07 July 2006 | Largest baseball | 3.6 metre(s) | All-Star Fan Fest |
| 05 July 2006 | Most cucumbers harvested from one plant in one year | | Walt Disney World Company |
| July 2006 | Largest cucumber plant | 56.7 square metre(s) | Walt Disney World Company |
| 28 June 2006 | Largest collection of chicken-related items | 6505 total number | Cecil and Joann Dixon |
| 20 June 2006 | Largest collection of mugs | 6352 total number | Bob Thomson |
| 14 June 2006 | Most expensive flag sold at auction | 12,336,000 UK pound(s) sterling | American Revolutionary War Battleflag (1776–1779) |
| 12 June 2006 | Fastest time to hula hoop 10 km (male) | 1/25/9 hour(s):minute(s):second(s) | Ashrita Furman |
| 12 June 2006 | Greatest distance covered in an inflatable craft in 24 hrs on flowing water | 312.55 kilometre(s) | Chris Reeder |
| June 2006 | Largest pinhole camera photograph | | The Legacy Project |
| 28 May 2006 | First person to win Indianapolis 500 after taking the lead on the final lap | first | Sam Hornish Jr. |
| 21 May 2006 | Farthest distance between two rounds of golf played on the same day | | John Knobel |
| 05 May 2006 | Most expensive baseball autographed sold at auction | 191200 US dollar(s) | DiMaggio, Monroe |
| May 2006 | Largest collection of versions of one song | 3049 total number | Allan Chasanoff and Raymon Elozua |
| 21 April 2006 | Tallest sugar sculpture | | Regis Courivaud |
| 21 April 2006 | Tallest cooked sugar sculpture | 3.91 metre(s) | Alain Roby |
| 20 April 2006 | Most tomatoes harvested from one plant in one year | | Walt Disney World Company |
| 20 April 2006 | Highest pizza toss | 6.52 metre(s) | Joe Carlucci |
| 20 April 2006 | Largest pizza base spun in two minutes | 2 centimetre(s) | Tony Gemignani |
| 18 April 2006 | Longest winning streak at the end of a NHL ice hockey season | | New Jersey Devils |
| 17 April 2006 | Youngest person to score 100 points in an NHL ice hockey season | | Sidney Crosby |
| 17 April 2006 | First person to score 100 points in an NHL ice hockey season as a rookie | first | Sidney Crosby |
| 17 April 2006 | Most modelling balloon sculptures made in 24 hours | 6176 total number | Tim Thurmond |
| 30 March 2006 | Most coronary stent implants | 34 total number | EMIL LOHEN |
| 28 March 2006 | Most modelling balloons blown up in one hour | | John Cassidy |
| 28 March 2006 | Fastest modelling balloon dog | 6.5 second(s) | John Cassidy |
| 23 March 2006 | Longest career as a music teacher | 76 year(s):day(s) | Charles Wright |
| 21 March 2006 | First tweet | first | Jack Dorsey |
| 18 March 2006 | Most triathlons completed | | James Lyle |
| 12 March 2006 | Farthest distance survived in a tornado | | Matt Suter |
| 12 March 2006 | Largest litter of goats | | Melanie Hall |
| 11 March 2006 | First soundtrack from a television film to top the US charts | first | High School Musical |
| 06 March 2006 | Top Fuel Dragbike racing, fastest speed | 245.36 mile(s) per hour | Larry McBride |
| March 2006 | Most published works by one author | 1084 total number | L. Ron Hubbard |
| March 2006 | Oldest person to reach top 10 of US club chart | | Bent Fabric |
| 28 February 2006 | Most expensive horse sold at auction | 16000000 US dollar(s) | Forestry colt |
| 26 February 2006 | Oldest person to win a NHRA Pro Stock event | | Warren Johnson |
| 26 February 2006 | Most expensive wedding dress | 12000000 US dollar(s) | Martin Katz Jewellers and Renee Strauss wedding dress |
| 19 February 2006 | Longest time to spin a basketball on one finger, maintaining spin | 4/15 hour(s):minute(s):second(s) | Joseph Odhiambo |
| 19 February 2006 | Youngest individual to win Most Valuable Player award of All-Star game | | LeBron James |
| 15 February 2006 | Largest digital graphic | 929 square metre(s) | Scott Lefeber |
| 05 February 2006 | Youngest person to win the Super Bowl as a quarterback | | Ben Roethlisberger |
| 05 February 2006 | Thinnest chip | | Hitachi |
| 28 January 2006 | Most rifle exchanges by team in a minute | 32 total number | Constantine Wilson |
| 28 January 2006 | Most underhand in-line rifle exchanges in one minute | | Constantine H. Wilson |
| 28 January 2006 | Most synchronized two hand rifle spins in one minute (team) | 168 total number | Constantine Wilson |
| 22 January 2006 | Largest orange by circumference | 63.5 centimetre(s) | Patrick Fiedler |
| 18 January 2006 | Most expensive kidney stone | 25000 US dollar(s) | William Shatner |
| 2006 | First person to win Daytona 500, Allstate 400 and NASCAR Nextel Cup Championship | first | Jimmie Johnson |
| 2006 | Most expensive film based on a comic-book character | 270000000 US dollar(s) | Superman Returns |
| 2006 | First novel of graphic style shortlisted for a national book award | | Gene Luen Yang |
| 2006 | Most Oscar nominations without winning - actor | 8 total number | Peter O'Toole |
| 2006 | Youngest person to compete in the Wild West Arts contest | | Maxwell William Mobley |
| 2006 | First person to change from Formula One driving to NASCAR | first | Juan Pablo Montoya |
| 2006 | Most NHL wins, one road trip | | Phildelphia Flyers |
| 2006 | Rarest bumblebee | | Franklin’s bumblebee (Bombus franklini) |
| 2006 | Greatest prize money for science and technology | 1000000 euro(s) | Millennium Technology Prize |
| 2006 | Largest supplier of arms to developing nations | 34100000000 US dollar(s) | USA |
| 2006 | First person to win a NHRA Pro Stock Motorcycle championship (female) | first | Angelle Sampey |
| 2006 | Largest autoclave | 2321 cubic metre(s) | ASC Process Systems |
| 2006 | First time to rush 1,000 yards in an NFL season by a quarterback and running back duo | first | Michael Vick, Warrick Dunn |
| 2006 | First person to score 800 points in a WNBA season | first | Diana Taurasi |
| 2006 | First remake to win a Best Picture Oscar | first | The Departed |
| 2006-2010 | Most consecutive wins of Male Vocalist of the Year at the Academy of Country Music Awards | | Brad Paisley |
| 2006 | Largest radar, phased array X-band | | SBX |
| 2006 | Youngest person to win the Wild West Arts'Texas skip race | | Cody Lamb |
| 2006 | Oldest person to win a class championship at the World Horseshoe Pitchers Tournament | | Bob Champion |
| 2006 | Largest producer of genetically modified seeds | 7344000000 US dollar(s) | Monsanto |
| 2006 | Most prolific Cooking Mama record breaker | | William Willemstyn III |
| 2006 | First brothers to receive Oscar nominations for best actor | | Joaquin Phoenix, River Phoenix |