| December 2000 | Longest solid object swallowed by dog | 38.1 centimetre(s) | Unknown |
| December 2000 | Largest hovercraft, civillian | | SRN4 Mk III |
| 14 November 2000 | Oldest operating scotch whisky distillery | | Strathisla Distillery |
| 11 November 2000 | Slot car distance in 24 hours (1:64 scale) | | Team USA 1 |
| October 2000 | Loudest scream (individual) | 129 decibel(s) (A-weighted) | Jill Drake |
| 24 September 2000 | Youngest person to score a century break in snooker | | Michael White |
| 06 September 2000 | Fastest circumnavigation by microlight | 99 day(s):hour(s):minute(s) | Colin Bodill |
| 06 September 2000 | Fastest circumnavigation by helicopter (female) | 99 day(s) | Jennifer Murray |
| 22 August 2000 | Longest wheelchair push - 24 hours | | Cumbria Cerebral Palsy Society |
| 30 July 2000 | Most beer mats snatched | | Dean Gould |
| 12 July 2000 | First use of forensic gait analysis evidence in court | first | Haydn Kelly |
| 04 May 2000 | Most piercings, single count (female) | | Elaine Davidson |
| 27 April 2000 | Fastest human calculator | 15 total number | Scott Flansburg |
| 19 April 2000 | First virtual newscaster | first | Ananova |
| 12 April 2000 | Largest telecoms company merger | 103400000000 UK pound(s) sterling | Vodafone Group |
| April 2000 | Largest collection of traffic cones | 137 total number | David Morgan |
| 29 March 2000 | Greatest speed achieved riding a kayak on snow | 62.94 kilometre(s) per hour | Shaun Baker |
| 21 March 2000 | Fastest circumnavigation by scheduled flights through exact antipodal points | 62/15 hour(s):minute(s) | Brother Michael Bartlett, David Springbett |
| 14 March 2000 | Largest simultaneous hat spin - one hand | | Francois Chotard |
| 08 March 2000 | Oldest Heavy Goods Vehicle (HGV) licence holder | 1919/11/13 year(s):day(s) | Robert Curry |
| 2000 | Most advanced underwater holographic camera | | HOLOMAR |
| 2000 | Lightest tank | first | Advanced Composite Armoured Vehicle Platform |
| 2000 | Best British Documentary Series of the 20th Century | | The World at War |
| 2000 | Fastest journey from Land's End to John-O'-Groats on tandem bicycle (mixed) | 51/19/23 hour(s):minute(s):second(s) | Andy Wilkinson, Lynne Taylor |
| 2000 | Most wins of the World Snail Racing Championships | | Thomas Vincent |