According to Official Guinness Records,
The most expensive letter sold at auction was sold for US$6,098,500 (£3,964,025;4,634,860€) on 10 April 2013 by Christie's, New York, USA, for a letter written by Francis Crick in 1953 to his son Michael Crick, outlining the revolutionary discovery of the structure and function of DNA.
In the seven-page handwritten letter 'Secret Of Life to his 12-year-old son, Francis Crick describes his discovery of the structure of DNA as something "beautiful". It includes a simple sketch of DNA's double helix structure. The letter was sold to an anonymous buyer.
For a complete list of 2013 records, please visit 2013 Guinness Records in United States.